A bend in a pipe costs pressure and it costs space. On the charge side, each bend adds resistance and disturbs the flow into the next component. On the exhaust side, each bend adds restriction the engine has to push against on every cycle.
So routing around an obstacle is not free, and moving the obstacle is not automatically better. The question is which of the two costs less in the place where it happens, and that depends on what the pipe is carrying and how much room the bay allows.
A washer bottle, a relay box, a horn or a plastic cover can usually be moved or reshaped. A crash beam, a suspension tower, a brake line and a fuel line cannot. The dividing line is whether the part carries structural load or fluid under pressure.
Between those groups sits a third: parts that can be moved but should not be, such as a control unit with a sealed connector or an impact sensor with a defined orientation. Those need the maker's procedure rather than a fabricator's judgement.
A pipe can be bent tighter than the flow wants and still fit. That is the trap: fit is a yes or a no, while flow is a gradual loss that only shows up as a lower reading or as a soft top end on the road, long after the job is finished.
Where a bend has to be tight, put it where the pipe is largest or where the flow is least disturbed. A tight bend immediately before a coupler is worse than the same bend further upstream, because the joint then sees uneven, distorted flow.
A rerouted pipe needs its own support. The original hanger points were placed for the original route, and a new route hanging from them puts load into the wrong place, usually at a weld or at a flange.
Support the run at sensible intervals, allow the pipe to move lengthways as it heats, and do not use the pipe itself as a structural member. A pipe that holds another component in place is a pipe that will crack at its bracket.
Every reroute adds joints, and every joint is a place where alignment has to be right. Two pipes meeting at an angle put a bending load into the coupler, and a coupler under bending load walks off the bead instead of staying put.
Aim for joints in straight sections, with the pipes parallel and the couplers long enough to take up movement. If a joint has to sit in a bend, use a formed hose rather than a straight length forced into a curve.
Move the obstacle when it is light, unpressurised and not structural, and when moving it removes more than one bend. Route around it when it is heavy, structural or fluid-carrying, or when the detour is short and gentle enough to cost nothing.
When the answer is a new route, the brief is a drawing rather than a description: start point, end point, and the envelope the pipe must stay inside. That is what a custom pipe run needs before anyone cuts metal, and it is what makes a charge pipe kit fit the first time.